Cyclohexanamine, 4-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Cyclohexanamine, 4-(1-methylethyl)- (9CI)
• CAS No.: 52430-81-6
• Molecular Formula: C9H19N
• Molecular Weight: 141.257
• Hs Code.: 2921300090
• Mol file: 52430-81-6.mol

Synonyms:Cyclohexanamine, 4-(1-methylethyl)- (9CI)

Chemical Property of Cyclohexanamine, 4-(1-methylethyl)- (9CI)

Chemical Property:

• Refractive Index: 1.4610 to 1.4650
• Boiling Point: 90°C/20mmHg(lit.)
• PKA: 10.57±0.70(Predicted)
• PSA: 26.02000
• Density: 0.850
• LogP: 2.86020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Propan-2-yl)cyclohexan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanamine, 4-(1-methylethyl)- (9CI)

There total 4 articles about Cyclohexanamine, 4-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Isopropylaniline (99-88-7) → 4-isopropylcyclohexylamine (52430-81-6)

Guidance literature:

With hydrogen; 5percent Rh/Al₂O₃; In isopropyl alcohol; at 80 ℃; for 18h; under 75007.5 Torr;

DOI:10.1021/jm0209174

Reference yield:

benzyl-(4-isopropylcyclohexyl)amine (1087351-22-1) → 4-isopropylcyclohexylamine (52430-81-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; for 16h;

Reference yield:

4-Isopropylcyclohexanone oxime (103027-46-9) → 4-isopropylcyclohexylamine (52430-81-6)

Guidance literature:

With hydrogen; nickel;

DOI:10.1021/jm00289a011

upstream raw materials:

4-Isopropylcyclohexanone oxime

4-Isopropylaniline

benzyl-(4-isopropylcyclohexyl)amine

Downstream raw materials:

4-isopropylcyclohexylamine hydrochloride salt

3-(4-isopropylcyclohexyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

Refernces

• 1、 Kolczewski, Sabine,Adam, Geo,Cesura, Andrea M.,Jenck, Fran?ois,Hennig, Michael,Oberhauser, Thomas,Poli, Sonia M.,R?ssler, Felix,R?ver, Stephan,Wichmann, Jürgen,Dautzenberg, Frank M.. "Novel hexahydrospiro[piperidine-4,1′-pyrrolo[3,4-c]pyrroles: Highly selective small-molecule nociceptin/orphanin FQ receptor agonists". . p. 255 - 264. Retrieved 2007/10/03.