cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on

Base Information

• Chemical Name: cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on
• CAS No.: 252285-20-4
• Molecular Formula: C14H25NO
• Molecular Weight: 223.359
• DSSTox Substance ID: DTXSID80451758
• Mol file: 252285-20-4.mol

Synonyms:cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on;252285-20-4;SCHEMBL550870;SCHEMBL7012317;DTXSID80451758;FFRMQGVGWFANKQ-BETUJISGSA-N;cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-one

Chemical Property of cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 223.193614421
• Heavy Atom Count: 16
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1CCC(CC1)N2CCC(=O)CC2

Technology Process of cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on

There total 2 articles about cis-1-(4-Isopropyl-cyclohexyl)-piperidine-4-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.7%

4-isopropylcyclohexylamine (52430-81-6) + 1-methyl-1-ethyl-4-oxopiperidinium iodide (77542-18-8) → cis-1-(4-isopropylcyclohexyl)piperidin-4-one (252285-20-4) + trans-1-(4-isopropylcyclohexyl)piperidin-4-one (494863-58-0)

Guidance literature:

With potassium carbonate; for 2h; Heating;

DOI:10.1021/jm0209174

Reference yield:

N-ethyl-4-piperidone (3612-18-8) → cis-1-(4-isopropylcyclohexyl)piperidin-4-one (252285-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / acetone / 23 h / 20 - 25 °C

2: 35.7 percent / aq. K₂CO₃ / 2 h / Heating

With potassium carbonate; In acetone;

DOI:10.1021/jm0209174

Reference yield: 70.0%

3-(2-aminophenyl)-[1,2,4]triazole (6219-58-5) + cis-1-(4-isopropylcyclohexyl)piperidin-4-one (252285-20-4) → C22H31N5 (901779-79-1)

Guidance literature:

With sulfuric acid; acetic acid; at 20 ℃;

DOI:10.1248/cpb.54.611

upstream raw materials:

4-isopropylcyclohexylamine

1-methyl-1-ethyl-4-oxopiperidinium iodide

N-ethyl-4-piperidone

Downstream raw materials:

cis-[1-(4-isopropylcyclohexyl)piperidin-4-ylidene]phenylamine

(4-fluorophenyl)-1-[1-(cis-4-isopropylcyclohexyl)piperidin-4-ylidene]amine

C₂₂H₃₁N₅