3,4-Dihydro-1(2H)-azulenone

Base Information

• Chemical Name: 3,4-Dihydro-1(2H)-azulenone
• CAS No.: 52487-41-9
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• DSSTox Substance ID: DTXSID80472044
• Nikkaji Number: J1.489.819K
• Mol file: 52487-41-9.mol

Synonyms:3,4-DIHYDRO-1(2H)-AZULENONE;52487-41-9;DTXSID80472044

Chemical Property of 3,4-Dihydro-1(2H)-azulenone

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 146.073164938
• Heavy Atom Count: 11
• Complexity: 279

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)C2=C1CC=CC=C2

Technology Process of 3,4-Dihydro-1(2H)-azulenone

There total 4 articles about 3,4-Dihydro-1(2H)-azulenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,3a-dihydro-1(2H)-azulenone (165336-31-2) → 1,2,3,4-tetrahydroazulen-1-one (52487-41-9)

Guidance literature:

With triethylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/0040-4039(95)00491-T

Reference yield: 71.0%

1-diazo-4-phenyl-2-butanone (10290-42-3) → 1,2,3,4-tetrahydroazulen-1-one (52487-41-9)

Guidance literature:

In 1,2-dichloro-ethane;

DOI:10.1021/ja00329a036

Reference yield:

3,8a-Dihydroazulen-1(2H)-one (90266-03-8) → 1,2,3,4-tetrahydroazulen-1-one (52487-41-9)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h; Yield given; Ambient temperature;

DOI:10.1039/P19900001047

upstream raw materials:

1-diazo-4-phenyl-2-butanone

3,8a-Dihydroazulen-1(2H)-one

3,3a-dihydro-1(2H)-azulenone

diazomethane

Downstream raw materials:

1-Oxo-indan-4-carbaldehyde

3,3a,4,7-tetrahydro-3a,7-epidioxy-1(2H)-azulenone

3,4,5,6-tetrahydro-5,8-epidioxy-1(2H)-azulenone

inden-1-one

Refernces

• 1、 Scott,L.T.,Gruetter,P.,Chamberlain,R.E.. "-". . p. 4852. Retrieved 1984.
• 2、 Rueedi, Georg,Hansen, Hans-Juergen. "New results in homoheptalene chemistry". . p. 1017 - 1047. Retrieved 2007/10/03.
• 3、 Kennedy, Michael,McKervey, M. Anthony,Maguire, Anita R.,Tuladhar, Sarbajna M.,Twohig, M. Fiona. "The Intramolecular Buchner Reaction of Aryl Diazoketones. Substituent Effects and Scope in Synthesis". . p. 1047 - 1054. Retrieved 2007/10/02.