3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Base Information

Chemical Name:3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol
CAS No.:137517-56-7
Molecular Formula:C₂₁H₂₉NO
Molecular Weight:311.467
Hs Code.:

Synonyms:3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Suppliers and Price of 3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

There total 7 articles about 3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137517-49-8
trans-2-(cyclobutylmethyl)decahydro-4a-(3-methoxyphenyl)-6-methyleneisoquinoline

: 137517-56-7
3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Guidance literature:: With lithium methanethiolate; In N,N-dimethyl-formamide; at 125 ℃; for 7h;
DOI:10.1021/jm00079a005

Reference yield:

: 82359-61-3
4-bromo-2-(bromomethyl)-1-butene

: 137517-56-7
3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 88 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 1.5 h / Heating

4: 74 percent / 50percent aq. KOH / ethanol / 17 h / Heating

5: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

6: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

7: LiSMe / dimethylformamide / 7 h / 125 °C

With potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; methanesulfonic acid; lithium methanethiolate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a005

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 137517-56-7
3-((4aS,8aS)-2-Cyclobutylmethyl-6-methylene-octahydro-isoquinolin-4a-yl)-phenol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 88 percent / i-Pr₂NEt / 1,2-dichloro-ethane / 1.5 h / Heating

4: 74 percent / 50percent aq. KOH / ethanol / 17 h / Heating

5: Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

6: LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

7: LiSMe / dimethylformamide / 7 h / 125 °C

With potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; methanesulfonic acid; lithium methanethiolate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00079a005