2-(Benzyloxy)-3-bromopyridine

Base Information

• Chemical Name: 2-(Benzyloxy)-3-bromopyridine
• CAS No.: 52200-49-4
• Molecular Formula: C12H10BrNO
• Molecular Weight: 264.121
• Hs Code.: 2933399090
• Mol file: 52200-49-4.mol

Synonyms:2-Benzyloxy-3-bromopyridine;

Chemical Property of 2-(Benzyloxy)-3-bromopyridine

Chemical Property:

• Vapor Pressure: 0.000426mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 325.8 °C at 760 mmHg
• PKA: 1.56±0.22(Predicted)
• Flash Point: 150.9 °C
• PSA: 22.12000
• Density: 1.438
• LogP: 3.42310
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzyloxy)-3-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Benzyloxy)-3-bromopyridine

There total 3 articles about 2-(Benzyloxy)-3-bromopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-bromo-2-chloropyridine (52200-48-3) + benzyl alcohol (100-51-6,185532-71-2) → 3-bromo-2-(phenylmethoxy)pyridine (52200-49-4)

Guidance literature:

benzyl alcohol; With potassium hydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

3-bromo-2-chloropyridine; In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1002/cmdc.201402075

Reference yield: 95.0%

3-bromopyridin-2(1H)-one (13466-43-8) + benzyl bromide (100-39-0) → 3-bromo-2-(phenylmethoxy)pyridine (52200-49-4)

Guidance literature:

With silver carbonate; In benzene; at 40 - 50 ℃; for 24h;

DOI:10.3987/COM-89-5142

Reference yield: 52.0%

3-bromo-pyridin-2-ol (13466-43-8) + benzyl bromide (100-39-0) → 3-bromo-2-(phenylmethoxy)pyridine (52200-49-4)

Guidance literature:

3-bromo-pyridin-2-ol; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

benzyl bromide; In DMF (N,N-dimethyl-formamide); at 20 ℃;

upstream raw materials:

3-bromopyridin-2(1H)-one

benzyl bromide

3-bromo-pyridin-2-ol

3-bromo-2-chloropyridine

Downstream raw materials:

3-bromo-2-chloropyridine

2-benzyloxy-3-diphenylphosphanyl-pyridine

(2-benzyloxy-3-pyridyl)boronic acid

2-(benzyloxy)-N-phenylpyridin-3-amine

Refernces

• 1、 Scarbaci, Kety,Troiano, Valeria,Ettari, Roberta,Pinto, Andrea,Micale, Nicola,Di Giovanni, Carmen,Cerchia, Carmen,Schirmeister, Tanja,Novellino, Ettore,Lavecchia, Antonio,Zappalà, Maria,Grasso, Silvana. "Development of novel selective peptidomimetics containing a boronic acid moiety, targeting the 20s proteasome as anticancer agents". . p. 1801 - 1816. Retrieved 2014/08/18.
• 2、 -. "Inhibitors of HCV replication". Page/Page column 181-182. . Retrieved 2010/10/20.