(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Base Information

Chemical Name:(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
CAS No.:938464-77-8
Molecular Formula:C₃₅H₃₆F₆N₂O₆
Molecular Weight:694.671
Hs Code.:

Synonyms:(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

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Chemical Property of (S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

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Technology Process of (S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

There total 4 articles about (S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (S)-6-(3,5-bis-trifluoromethylbenzylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid trifluoroacetate

: 24424-99-5
di-tert-butyl dicarbonate

: 938464-77-8
(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ja069128s

Reference yield: 98.0%

: 938464-88-1
(S)-4-[(3,5-bis-trifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: (S)-6-(3,5-Bis-trifluoromethyl-benzylamino)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid trifluoroacetate

: 938464-77-8
(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Guidance literature:: In dichloromethane;

Reference yield:

: N_αFmoc-lysine trifluoro acetic acid

: 938464-77-8
(S)-6-[(3,5-bistrifluoromethylbenzyl)tert-butoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / sodium triacetoxyborohydride; trifluoroacetic acid / dimethylformamide / 1 h / 20 °C

2: 98 percent / aq. NaHCO₃ / CH₂Cl₂ / 3 h / 20 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja069128s