1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI)

Base Information

• Chemical Name: 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI)
• CAS No.: 52090-62-7
• Molecular Formula: C8H7N3O
• Molecular Weight: 161.163
• Hs Code.: 2933990090
• Mol file: 52090-62-7.mol

Synonyms:1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI)

Chemical Property of 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI)

Chemical Property:

• Boiling Point: 323.9±34.0 °C(Predicted)
• PKA: 2.17±0.30(Predicted)
• PSA: 47.78000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 1.09140
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

1-(1H-Pyrazolo[4,3-b]pyridin-1-yl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI)

There total 5 articles about 1H-Pyrazolo[4,3-b]pyridine, 1-acetyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-methyl-3-pyridinamine (3430-10-2) + acetic anhydride (108-24-7) → 1-(1H-pyrazolo[4,3-b]pyridin-1-yl)-ethan-1-one (52090-62-7)

Guidance literature:

2-methyl-3-pyridinamine; acetic anhydride; In chloroform; at 0 - 20 ℃;

With potassium acetate; isopentyl nitrite; In chloroform; Reflux;

Reference yield:

N-(2-methyl-pyridin-3-yl)-acetamide (34050-39-0) → 1-(1H-pyrazolo[4,3-b]pyridin-1-yl)-ethan-1-one (52090-62-7)

Guidance literature:

With isoamyl sulfite; potassium acetate; acetic anhydride; In toluene; at 80 ℃; for 2h;

Reference yield:

2-methyl-3-pyridinamine (3430-10-2) → 1-(1H-pyrazolo[4,3-b]pyridin-1-yl)-ethan-1-one (52090-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: chloroform / 1 h / Inert atmosphere

2: potassium acetate; isopentyl nitrite / 15 h / 60 - 65 °C / Inert atmosphere

With potassium acetate; isopentyl nitrite; In chloroform;

DOI:10.1021/jacs.1c07060

upstream raw materials:

N-(2-methyl-pyridin-3-yl)-acetamide

2-methyl-3-pyridinamine

acetic anhydride

potassium acetate

Downstream raw materials:

1H-pyrazolo-[4,3-b]-pyridine

N⁵-((R)-3-(acetylthio)-1-((carboxymethyl)amino)-1-oxopropan-2-yl)-L-glutamine

Refernces

• 1、 Adamson, Christopher,Kajino, Hidetoshi,Kanai, Motomu,Kawashima, Shigehiro A.,Yamatsugu, Kenzo. "Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis". supporting information. p. 14976 - 14980. Retrieved 2021/09/29.
• 2、 -. "PYRAZOLE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME". Page/Page column 134-135. . Retrieved 2008/06/13.