2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

Base Information

Chemical Name:2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine
CAS No.:1311109-56-4
Molecular Formula:C₃₆H₃₂ClN₅O₉
Molecular Weight:714.131
Hs Code.:

Synonyms:2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

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Chemical Property of 2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

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Technology Process of 2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

There total 3 articles about 2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl ortho-hexynylbenzoate

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1311109-56-4
2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

Guidance literature:: 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl ortho-hexynylbenzoate; 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1002/anie.201100514

Reference yield: 81.0%

: 1311109-66-6
C₃₉H₃₄O₉

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1311109-56-4
2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

Guidance literature:: C₃₉H₃₄O₉; 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine; In dichloromethane; at 20 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; for 2h; Molecular sieve; Inert atmosphere;
DOI:10.1021/acs.joc.1c00151

Reference yield: 75.0%

: 918800-27-8
p-tolyl 2,3,5-tri-O-benzoyl-1-thio-β-D-ribofuranoside

: 2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine

: 1311109-56-4
2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

Guidance literature:: p-tolyl 2,3,5-tri-O-benzoyl-1-thio-β-D-ribofuranoside; With trifluoromethylsulfonic anhydride; di(p-tolyl) sulfoxide; In dichloromethane; at -50 - -40 ℃; for 0.833333h; Molecular sieve;

2-(N-tert-butoxycarbonyl)amino-6-chloro-9H-purine; In dichloromethane; acetonitrile; at -50 - 20 ℃; stereoselective reaction;
DOI:10.1039/c5cc03617h