2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Base Information

• Chemical Name: 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine
• CAS No.: 3387-63-1
• Molecular Formula: C₃₁H₂₄ClN₅O₇
• Molecular Weight: 614.014
• Mol file: 3387-63-1.mol

Synonyms:2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Chemical Property of 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine

There total 7 articles about 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine (1311109-56-4) → 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (3387-63-1)

Guidance literature:

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201100514

Reference yield: 83.0%

2-Amino-6-chloropurin (10310-21-1) + 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (3387-63-1)

Guidance literature:

2-Amino-6-chloropurin; With ammonium sulfate; 1,1,1,3,3,3-hexamethyl-disilazane; Heating;

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane;

DOI:10.1016/S0960-894X(03)00020-9

Reference yield: 73.0%

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (14215-97-5) → 2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine (3387-63-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 0 - 70 ℃; for 16h;

upstream raw materials:

2-Amino-6-chloropurin

1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

2-tert-butoxycarbonylamino-6-chloro-9-(2’,3’,5’-tri-O-benzoyl-β-D-ribofuranosyl)purine

Downstream raw materials:

C₃₁H₂₂ClIN₄O₇

2-Amino-6-chloropurine riboside

6-O-methylguanosine

adenosine-2-amine