4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

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Chemical Name:4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol
CAS No.:1550168-36-9
Molecular Formula:C₂₂H₁₅F₃N₈O₃
Molecular Weight:496.408
Hs Code.:

Synonyms:4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

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Chemical Property of 4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

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Technology Process of 4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

There total 2 articles about 4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1550170-74-5
6-phenyl-1-(prop-2-ynyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

: 51642-26-3
2-nitro-4-azidophenol

: 1550168-36-9
4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.12.107

Reference yield:

: 201224-86-4
6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

: 1550168-36-9
4-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-2-nitrophenol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetone / 24 h / 20 - 60 °C

2: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmcl.2013.12.107