201224-86-4

Basic information

• Product Name: 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine
• Synonyms: 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine
• CAS NO: 201224-86-4
• Molecular Weight: 278.236
• Mol File: 201224-86-4.mol

Chemical Properties

• CAS DataBase Reference: 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine(201224-86-4)
• EPA Substance Registry System: 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine(201224-86-4)

Safety Data

• Hazardous Substances Data: 201224-86-4(Hazardous Substances Data)

Upstream product

• 3335-44-2 2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile 
• 155635-57-7 2-((3-cyano-6-phenyl-4-(trifluoromethyl)pyridin-2-yl)oxy)acetamide 

Downstream Products

• 1469293-82-0 ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate 
• 1469293-87-5 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-(2-aminoethyl)acetamide 
• 1469293-89-7 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-cyclopropylacetamide 
• 1469293-90-0 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-(furan-2-ylmethyl)acetamide 
• 1469293-91-1 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-cyclohexylacetamide 
• 1469293-92-2 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-benzylacetamide 
• 1469293-93-3 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone 
• 1469293-94-4 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-methylpiperazin-1-yl)ethanone 
• 1469293-95-5 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-(2-hydroxyethyl)piperazin-1-yl)ethanone 
• 1469293-96-6 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(4-phenylpiperazin-1-yl)ethanone 
• 1469293-97-7 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-(piperidin-1-yl)ethanone 
• 1550170-74-5 6-phenyl-1-(prop-2-ynyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 1550167-86-6 6-phenyl-1-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 1550167-80-0 1-((1-octyl-1H-1,2,3-triazol-4-yl)methyl)-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 

Relevant articles and documents

Synthesis and anticancer activity of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives

A series of novel oxadiazole functionalized pyrazolo[3,4-b]pyridine derivatives (6a-n) was synthesized using 6-thiophenyl-4- (trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine (1) through reaction with 2-bromoethyl acetate, followed by hydrazine hydrate

Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents

A series of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives 5, 6 and 7 were prepared starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 3 via selective N-alkylation, followed by reaction with different primary aliphatic amines, cyclic secondary amines or l-amino acids under different set of conditions. All the synthesized compounds 5, 6 and 7 were screened for anticancer activity against four cancer cell lines such as A549 - Lung cancer (CCL-185), MCF7 - Breast cancer (HTB-22), DU145 - Prostate cancer (HTB-81) and HeLa - Cervical cancer (CCL-2). The compounds 5i and 6e are found to have promising bioactivity at micro molar concentration.

A new synthetic route to fluorinated pyrazolo[3,4-b]pyridines and their use in the preparation of novel pyrido[2′,3′:3,4] pyrazolo [1,5-a]pyrimidines

A single-step synthesis of 3-amino-4-trifluoromethyl-6-substituted-1H-pyrazolo[3,4-b]pyridines (7) from 2-0-acetamido-3-cyano-4-trifluoromethyl-6-substituted pyridines (6) is described, and their use in the synthesis of novel pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidines(8) under microwave irradiation outlined.