LHRH (1-5) HYDRAZIDE

Base Information

• Chemical Name: LHRH (1-5) HYDRAZIDE
• CAS No.: 51871-40-0
• Molecular Formula: C₃₄H₄₀N₁₀O₈
• Molecular Weight: 716.754
• Mol file: 51871-40-0.mol

Synonyms:LHRH (1-5) HYDRAZIDE;GONADOTROPIN-RELEASING HORMONE (1-5) HYDRAZIDE;LUTEINIZING HORMONE-RELEASING FACTOR (1-5) HYDRAZIDE;LUTEINIZING HORMONE-RELEASING HORMONE (1-5) HYDRAZIDE;PYROGLU-HIS-TRP-SER-TYR-HYDRAZIDE;PYR-HIS-TRP-SER-TYR-NHNH2

Chemical Property of LHRH (1-5) HYDRAZIDE

Chemical Property:

• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of LHRH (1-5) HYDRAZIDE

There total 1 articles about LHRH (1-5) HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester (51871-39-7) → Glp-His-Trp-Ser-Tyr-N2H3 (51871-40-0)

Guidance literature:

With hydrazine hydrate; In methanol; for 24h; Yield given;

Reference yield:

Glp-His-Trp-Ser-Tyr-N2H3 (51871-40-0) → Glp-His-Trp-Ser-Tyr-N3 (51871-41-1)

Guidance literature:

With hydrogenchloride; sodium nitrite; In N,N-dimethyl-formamide; at -20 - -10 ℃; for 0.25h;

Reference yield:

Glp-His-Trp-Ser-Tyr-N2H3 (51871-40-0) → D-Phe(6)-GnRH(1-9)-EA (57773-64-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 6N HCl, conc. aq NaNO₂ / dimethylformamide / 0.25 h / -20 - -10 °C

2: Et₃N / dimethylformamide / 48 h / 0 °C

3: H₂, 1N aq KOH / 10percent Pd-CaCO₃ / dimethylformamide

With hydrogenchloride; potassium hydroxide; hydrogen; triethylamine; sodium nitrite; Lindlar's catalyst; In N,N-dimethyl-formamide;

upstream raw materials:

L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester

Downstream raw materials:

Glp-His-Trp-Ser-Tyr-N₃

D-Phe⁽⁶⁾-GnRH(1-9)-EA

D-Cpa⁽⁶⁾-GnRH(1-9)-EA