Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester

Base Information

Chemical Name:Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester
CAS No.:51871-39-7
Molecular Formula:C35H40 N8 O9
Molecular Weight:716.74
Hs Code.:
DSSTox Substance ID:DTXSID30199835
Wikidata:Q83072840
Mol file:51871-39-7.mol

Synonyms:GHTST;pGlu-His-Trp-Ser-Tyr-OMe;pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester

Suppliers and Price of Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:1304.3°C at 760 mmHg
Flash Point:742.6°C
PSA：274.18000
Density:1.421g/cm³
LogP:2.64470
XLogP3:0.2
Hydrogen Bond Donor Count:9
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:17
Exact Mass:716.29182488
Heavy Atom Count:52
Complexity:1280

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CO)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CN=CN4)NC(=O)C5CCC(=O)N5
Isomeric SMILES:COC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](CC4=CN=CN4)NC(=O)[C@@H]5CCC(=O)N5

Technology Process of Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester

There total 9 articles about Pyroglutamyl-histidyl-tryptophyl-seryl-tyrosyl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 67-56-1
methanol

: 52434-75-0
pGlu-His-Trp-Ser-Tyr

: 51871-39-7
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester

Guidance literature:: With boron trifluoride; at 0 ℃; for 8h;

Reference yield:

: 49760-73-8
H-Ser-Tyr-OMe * HCl

: Glp-His-Trp-N₃

: 51871-39-7
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 ℃; for 20h;

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 51871-39-7
L-pyroglutamyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / dioxane / 5 h / papain, dithioerythritol in phosphate buffer, pH 9

2: deprotection

3: 67 percent / methanol; H₂O / 16 h / Ambient temperature; papain, dithioerythritol, pH 8

4: TFA, anisole / 3 h / 0 °C

5: 83 percent / 10percent BF₃ / 8 h / 0 °C

With boron trifluoride; methoxybenzene; trifluoroacetic acid; In 1,4-dioxane; methanol; water;