6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

Base Information

Chemical Name:6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate
CAS No.:1362239-46-0
Molecular Formula:C₁₇H₁₈ClN₅O₃
Molecular Weight:375.815
Hs Code.:

Synonyms:6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

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Chemical Property of 6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

Chemical Property:

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Technology Process of 6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

There total 4 articles about 6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1362239-42-6
6-chloro-2-methyl-9-[3-(N,N-dimethylamino)phenyl]purin-8-one

: 541-41-3
chloroformic acid ethyl ester

: 1362239-46-0
6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.ejmech.2012.01.022

Reference yield:

: 39906-04-2
5-amino-4,6-dichloro-2-methylpyrimidine

: 1362239-46-0
6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 2-methyl-propan-1-ol; water / 0.17 h / 150 °C / Sealed vial; Microwave irradiation

2: acetic anhydride / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation; Sealed vial

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

With hydrogenchloride; acetic anhydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; 2-methyl-propan-1-ol; water;
DOI:10.1016/j.ejmech.2012.01.022

Reference yield:

: 1362239-25-5
6-chloro-N₄-[3'-(N',N'-dimethylamino)phenyl]-2-methylpyrimidine-4,5-diamine

: 1362239-46-0
6-chloro-9-(3-(N,N-dimethylamino)phenyl)-2-methyl-9H-purin-8-yl ethyl carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation; Sealed vial

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2012.01.022