2-(3-Isopropylphenyl)ethyl Bromide

Base Information

• Chemical Name: 2-(3-Isopropylphenyl)ethyl Bromide
• CAS No.: 72646-50-5
• Molecular Formula: C₁₁H₁₅Br
• Molecular Weight: 227.144
• Mol file: 72646-50-5.mol

Synonyms:2-(3-Isopropylphenyl)ethyl Bromide

Chemical Property of 2-(3-Isopropylphenyl)ethyl Bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-Isopropylphenyl)ethyl Bromide

There total 2 articles about 2-(3-Isopropylphenyl)ethyl Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-isopropyl-phenethyl alcohol (68480-22-8) → 2-(3-Isopropylphenyl)ethyl Bromide (72646-50-5)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1248/cpb.39.202

Reference yield:

2-(3-isopropylphenyl)acetic acid (81049-21-0) → 2-(3-Isopropylphenyl)ethyl Bromide (72646-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.4 g / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 93 percent / PPh₃, N-bromosuccinimide / tetrahydrofuran / 2 h / Ambient temperature

With N-Bromosuccinimide; lithium aluminium tetrahydride; triphenylphosphine; In tetrahydrofuran;

DOI:10.1248/cpb.39.202

Reference yield:

2-(3-Isopropylphenyl)ethyl Bromide (72646-50-5) → 7-Isopropyl-3-phenyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one (111027-04-4)

Guidance literature:

Multi-step reaction with 6 steps

4: 85 percent

5: 75 percent / NH₂OH*HCl, NaOAc / methanol; H₂O / 4 h / Heating

6: 72 percent / polyphosphoric acid / 0.25 h / 120 °C

With PPA; hydroxylamine hydrochloride; sodium acetate; In methanol; water;

DOI:10.1021/jm00396a016

upstream raw materials:

3-isopropyl-phenethyl alcohol

2-(3-isopropylphenyl)acetic acid

Downstream raw materials:

3-(3-isopropyl-phenethyl)-2-methyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester

2-(3-isopropyl-phenethyl)-3-methyl-cyclohex-2-enone

3-(3-Isopropyl-phenyl)-1-(1-methyl-cyclopropyl)-propan-1-ol

(R)-2-(3-Hydroxy-propyl)-5-(3-isopropyl-phenyl)-2-methyl-3-nitromethyl-pentanoic acid methyl ester