(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

Base Information

Chemical Name:(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one
CAS No.:267661-39-2
Molecular Formula:C₃₄H₄₃NO₄Si
Molecular Weight:557.805
Hs Code.:

Synonyms:(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

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Chemical Property of (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

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Technology Process of (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

There total 5 articles about (3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 267661-10-9
(3S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-hexahydro-indolizin-5-one

: 74-88-4
methyl iodide

: 267661-39-2
(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0960-894X(99)00669-1

Reference yield:

: 181705-70-4
(5S,2'S,5'S)-5-[1'-(tert-butoxycarbonyl)-5'-(tert-butyldiphenylsilyloxymethyl)pyrrolidin-2'-yl]-2(5H)-furanone

: 267661-39-2
(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / 10 percent Pd/C / ethyl acetate

2: 71 percent / B-bromocatecholborane / CH₂Cl₂

3: 98 percent / NaOMe / methanol

4: 86 percent / Bu₄NI / tetrahydrofuran

5: 97 percent / t-BuLi / tetrahydrofuran / -78 °C

With bromocatecholborane; hydrogen; tert.-butyl lithium; sodium methylate; tetra-(n-butyl)ammonium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1: Catalytic hydrogenation / 2: Decarboxylation / 3: lactam formation / 4: Etherification / 5: Methylation;
DOI:10.1016/S0960-894X(99)00669-1

Reference yield:

: 181705-71-5
(5S,2'S,5'S)-5-[5'-(tert-butyldiphenylsilyloxymethyl)pyrrolidin-2'yl]-tetrahydrofuran-2-one

: 267661-39-2
(3S,6S,8S,8aS)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-8-(4-methoxy-benzyloxy)-6-methyl-hexahydro-indolizin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / NaOMe / methanol

2: 86 percent / Bu₄NI / tetrahydrofuran

3: 97 percent / t-BuLi / tetrahydrofuran / -78 °C

With tert.-butyl lithium; sodium methylate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; 1: lactam formation / 2: Etherification / 3: Methylation;
DOI:10.1016/S0960-894X(99)00669-1