(1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester
CAS No.:468717-96-6
Molecular Formula:C₂₄H₂₄N₂O₄S
Molecular Weight:436.532
Hs Code.:

Synonyms:(1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

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Chemical Property of (1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

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Technology Process of (1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

There total 2 articles about (1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 468717-94-4
1-(toluene-4-sulfonyl)-3-vinyl-1H-indole-5-carbonitrile

: 35059-50-8
t-butyl diazoacetate

: 468717-96-6
(1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: In toluene;

Reference yield:

: 17380-18-6
3-formyl-1H-indole-5-carbonitrile

: 468717-96-6
(1S,2S)-trans-2-[5-cyano-1-(p-toluenesulfonyl)indol-3-yl]-cyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran; hexane

2: toluene

With n-butyllithium; In tetrahydrofuran; hexane; toluene;