(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

Base Information

Chemical Name:(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate
CAS No.:1382995-94-9
Molecular Formula:C₂HF₃O₂*C₂₀H₁₉ClN₈O
Molecular Weight:536.901
Hs Code.:

Synonyms:(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

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Chemical Property of (4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

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Technology Process of (4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

There total 7 articles about (4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1382996-46-4
{4-[3-(1-aminoethyl)-5-chloro-2-methoxy-6-methylphenyl]-1H-pyrazol-1-yl}acetonitrile

: 767-69-1
6-bromopurine

: 76-05-1
trifluoroacetic acid

: 1382995-94-9
(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

Guidance literature:: {4-[3-(1-aminoethyl)-5-chloro-2-methoxy-6-methylphenyl]-1H-pyrazol-1-yl}acetonitrile; 6-bromopurine; With N-ethyl-N,N-diisopropylamine; In ethanol; at 100 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 28480-70-8
5'-chloro-2'-hydroxy-4'-methyl acetophenone

: 1382995-94-9
(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / acetic acid / 18 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C / Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran

5.1: sodium hydride / N,N-dimethyl-formamide; oil / 1 h / 0 - 20 °C

5.2: 1 h / 0 - 20 °C

6.1: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

7.1: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With hydrogenchloride; methanol; N-Bromosuccinimide; ammonium acetate; water; sodium hydride; sodium cyanoborohydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; oil;

Reference yield:

: 1-(3-bromo-5-chloro-2-hydroxy-4-methylphenyl)ethanone

: 1382995-94-9
(4-{3-Chloro-6-methoxy-2-methyl-5-[1-(9H-purin-6-ylamino)ethyl]phenyl}-1H-pyrazol-1-yl)acetonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / Reflux

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran

4.1: sodium hydride / N,N-dimethyl-formamide; oil / 1 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: methanol; ammonium acetate; sodium cyanoborohydride / tetrahydrofuran; acetonitrile / 65 °C

6.1: N-ethyl-N,N-diisopropylamine / ethanol / 100 °C

With hydrogenchloride; methanol; ammonium acetate; water; sodium hydride; sodium cyanoborohydride; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; oil;