2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

Base Information

Chemical Name:2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine
CAS No.:854280-07-2
Molecular Formula:C₃₄H₃₃NO₁₀P₂
Molecular Weight:677.584
Hs Code.:

Synonyms:2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

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Chemical Property of 2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

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Technology Process of 2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

There total 4 articles about 2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 854280-05-0
tert-butyl 2,6-dioxopiperidine-1-carboxylate

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 854280-07-2
2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: tert-butyl 2,6-dioxopiperidine-1-carboxylate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.9b00462

Reference yield:

: 1121-89-7
piperidine-2,6-dione

: 854280-07-2
2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / DMAP / acetonitrile / 15 h / 20 °C

2.1: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 64 percent / tetrahydrofuran; hexane / 15 h / -78 - 20 °C

With dmap; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1016/j.tetlet.2005.03.136

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 854280-07-2
2,6-bis[di(phenyloxy)phosphoryloxy]-1-(tert-butoxycarbonyl)-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / acetonitrile / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With dmap; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1021/acs.orglett.9b00462