(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

Base Information

Chemical Name:(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane
CAS No.:388602-51-5
Molecular Formula:C₂₃H₃₆O₂Si
Molecular Weight:372.623
Hs Code.:

Synonyms:(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

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Chemical Property of (4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

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Technology Process of (4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

There total 7 articles about (4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 388602-50-4
[(E)-(1S,2S)-1-((R)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-dec-5-en-3-ynyloxy]-dimethyl-silane

: 388602-51-5
(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

Guidance literature:: With dihydrogen hexachloroplatinate; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.1021/ol016899m

Reference yield:

: 79027-28-4
(2S)-3-(benzyloxy)-2-methylpropanal

: 388602-51-5
(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / HMPA; InI / Pd(OAc)2*PPh₃ / tetrahydrofuran / 0.25 h / 0 °C

2: 87 percent / Et₃N / CH₂Cl₂ / 20 °C

3: CuCl; 1,3-dimethylimidazolidin-2-one; Bu₃N / 10 h / 120 °C

4: 90 percent / TBAF / tetrahydrofuran / 10 h

5: 12 h / 60 °C

6: 85 percent / H₂PtCl₆ / tetrahydrofuran / 1 h / 60 °C

With 1,3-dimethyl-2-imidazolidinone; N,N,N,N,N,N-hexamethylphosphoric triamide; dihydrogen hexachloroplatinate; indium iodide; tributyl-amine; tetrabutyl ammonium fluoride; triethylamine; copper(l) chloride; Pd(PPh₃)(OAc)2; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016899m

Reference yield:

: 16644-98-7
(E)-1-iodohexene

: 388602-51-5
(4R,5R)-5-((R)-2-Benzyloxy-1-methyl-ethyl)-3-[(E)-hept-2-en-(E)-ylidene]-2,2,4-trimethyl-[1,2]oxasilolane

Guidance literature:: Multi-step reaction with 4 steps

1: CuCl; 1,3-dimethylimidazolidin-2-one; Bu₃N / 10 h / 120 °C

2: 90 percent / TBAF / tetrahydrofuran / 10 h

3: 12 h / 60 °C

4: 85 percent / H₂PtCl₆ / tetrahydrofuran / 1 h / 60 °C

With 1,3-dimethyl-2-imidazolidinone; dihydrogen hexachloroplatinate; tributyl-amine; tetrabutyl ammonium fluoride; copper(l) chloride; In tetrahydrofuran;
DOI:10.1021/ol016899m