methyl 4-chloro-2--3-hydroxycrotonate

Base Information

Chemical Name:methyl 4-chloro-2--3-hydroxycrotonate
CAS No.:84701-05-3
Molecular Formula:C₁₆H₁₈ClNO₄S
Molecular Weight:355.842
Hs Code.:

methyl 4-chloro-2-<trans-(3-ethyl-2-oxo-4-phenylthio-1-azetidinyl)>-3-hydroxycrotonate

Synonyms:methyl 4-chloro-2--3-hydroxycrotonate

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Chemical Property of methyl 4-chloro-2--3-hydroxycrotonate

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Technology Process of methyl 4-chloro-2--3-hydroxycrotonate

There total 3 articles about methyl 4-chloro-2--3-hydroxycrotonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.6%

: 82551-55-1
trans-3-ethyl-1-methoxycarbonylmethyl-4-phenylthioazetidin-2-one

: 79-04-9
chloroacetyl chloride

: 84701-05-3
methyl 4-chloro-2--3-hydroxycrotonate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.6h;
DOI:10.1016/0040-4020(82)85085-0

Reference yield:

: 82290-86-6
4-acetoxy-3-ethyl-azetidin-2-one

: 84701-05-3
methyl 4-chloro-2--3-hydroxycrotonate

Guidance literature:: Multi-step reaction with 3 steps

1: 98.1 percent / NaOH / methanol; H₂O / 0.25 h / Ambient temperature

2: 88.7 percent / lithium hexamethyldisilazide / tetrahydrofuran / 2.2 h / -78 - 25 °C

3: 79.6 percent / lithium hexamethyldisilazide / tetrahydrofuran / 0.6 h / -78 °C

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;
DOI:10.1016/0040-4020(82)85085-0

Reference yield:

: 82551-54-0
trans-3-ethyl-4-phenylthioazetidin-2-one

: 84701-05-3
methyl 4-chloro-2--3-hydroxycrotonate

Guidance literature:: Multi-step reaction with 2 steps

1: 88.7 percent / lithium hexamethyldisilazide / tetrahydrofuran / 2.2 h / -78 - 25 °C

2: 79.6 percent / lithium hexamethyldisilazide / tetrahydrofuran / 0.6 h / -78 °C

With lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/0040-4020(82)85085-0