N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

Base Information

Chemical Name:N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide
CAS No.:954426-22-3
Molecular Formula:C₃₃H₄₂N₆O₅SSi
Molecular Weight:662.885
Hs Code.:

Synonyms:N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

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Chemical Property of N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

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Technology Process of N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

There total 7 articles about N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 954426-16-5
(E)-N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-hydroxy-2-propenamide

: 954426-18-7
(2E)-3-(1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl)-2-propenyl tert-butyl carbonate

: 954426-22-3
N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

Guidance literature:: With triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/ol0711568

Reference yield:

: 954426-17-6
(2E)-3-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)prop-2-en-1-ol

: 954426-22-3
N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / Bu₄NHSO₄; aq. NaOH / CH₂Cl₂ / 3 h / 20 °C

2: 70 percent / PPh₃ / Pd₂(dba)3 / CH₂Cl₂ / 24 h / 20 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In dichloromethane;
DOI:10.1021/ol0711568

Reference yield:

: 574-66-3
Benzophenone oxime

: 954426-22-3
N-benzhydryl-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-N-(3-{1-[2-(trimethylsilyl)ethoxymethyl]-1H-imidazol-4-yl}allyloxy)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. HCl; NaBH₃CN / methanol / 4 h / 20 °C / pH 3

2: 6.94 g / Na₂SO₄; Et₃N / CH₂Cl₂ / 20 °C

3: 70 percent / PPh₃ / Pd₂(dba)3 / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; sodium sulfate; triethylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; dichloromethane;
DOI:10.1021/ol0711568