11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

Base Information

Chemical Name:11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene
CAS No.:940932-58-1
Molecular Formula:C₃₁H₃₇F₂NO₄
Molecular Weight:525.636
Hs Code.:

Synonyms:11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

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Chemical Property of 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

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Technology Process of 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

There total 9 articles about 11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 940932-57-0
17β-amino-11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxyestr-9-ene

: 79-03-8
propionyl chloride

: 940932-58-1
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ol070447d

Reference yield:

: 940932-55-8
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-nitroestr-9-ene

: 940932-58-1
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

Guidance literature:: Multi-step reaction with 3 steps

1: Zn; aq. NH₄Cl / tetrahydrofuran; ethanol / 0.5 h

2: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

3: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; borax; ammonium chloride; triethylamine; zinc; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d

Reference yield:

: 940932-56-9
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-(N-hydroxylamino)estr-9-ene

: 940932-58-1
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

2: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; borax; triethylamine; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d