N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

Base Information

Chemical Name:N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline
CAS No.:874306-45-3
Molecular Formula:C₅₆H₉₄N₄O₈
Molecular Weight:951.384
Hs Code.:

N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

Synonyms:N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

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Chemical Property of N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

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Technology Process of N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

There total 4 articles about N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 874306-28-2
(3α,5β)-3,24-bis(3-bromophenoxy)cholane

: 4246-51-9
4,7,10-trioxa-1,13-diaminotridecane

: 874306-45-3
N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

Guidance literature:: With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; Heating;

Reference yield:

: 20414-15-7,101046-88-2,20414-16-8
5β-cholane-3α,24-diol

: 874306-45-3
N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / PPh₃; EtO₂CN=NCO₂Et / toluene; tetrahydrofuran / 48 h / 20 °C

2: 2.89 g / PPh₃; EtO₂CN=NCO₂Et / toluene; tetrahydrofuran / 24 h / 45 - 50 °C

3: 82 percent / BINAP; t-BuONa / [Pd(dba)2] / dioxane / 8 h / Heating

With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; diethylazodicarboxylate; [Pd(dibenzylideneacetone)2]; In tetrahydrofuran; 1,4-dioxane; toluene; 1: Mitsunobu reaction / 2: Mitsunobu reaction;
DOI:10.1002/chem.200500784

Reference yield:

: 434-13-9
Lithocholic acid

: 874306-45-3
N-(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)-3-([(3β,5β,17α,20S)-24-{3-[(3-{2-[2-(3-aminopropoxy)ethoxy]ethoxy}propyl)amino]phenoxy}cholan-3-yl]oxy)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 2 h

2: 39 percent / PPh₃; EtO₂CN=NCO₂Et / toluene; tetrahydrofuran / 48 h / 20 °C

3: 2.89 g / PPh₃; EtO₂CN=NCO₂Et / toluene; tetrahydrofuran / 24 h / 45 - 50 °C

4: 82 percent / BINAP; t-BuONa / [Pd(dba)2] / dioxane / 8 h / Heating

With sodium tetrahydroborate; boron trifluoride diethyl etherate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triphenylphosphine; sodium t-butanolate; diethylazodicarboxylate; [Pd(dibenzylideneacetone)2]; In tetrahydrofuran; 1,4-dioxane; toluene; 2: Mitsunobu reaction / 3: Mitsunobu reaction;
DOI:10.1002/chem.200500784