(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate
CAS No.:942142-92-9
Molecular Formula:C₁₇H₂₄FNO₃
Molecular Weight:309.381
Hs Code.:

Synonyms:(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

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Technology Process of (R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

There total 2 articles about (R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 942142-91-8
(R)-tert-butyl 3-(3-fluorobenzoyl)piperidine-1-carboxylate

: 942142-92-9
(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

Guidance literature:: With borane-THF; In tetrahydrofuran; toluene; at -15 - 20 ℃; for 1h;

Reference yield:

: 942142-91-8
(R)-tert-butyl 3-(3-fluorobenzoyl)piperidine-1-carboxylate

: 942142-92-9
(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

: 1177419-25-8
C₁₇H₂₄FNO₃

Guidance literature:: With (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; benzo[1,3,2]dioxaborole; In toluene; at -14 ℃; for 16h; stereoselective reaction;
DOI:10.1016/j.bmcl.2009.04.140

Reference yield: 76.0%

: 942142-92-9
(R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate

: 105-36-2
ethyl bromoacetate

: 942142-93-0
(R)-tert-butyl 3-((R)-(2-ethoxy-2-oxoethoxy)(3-fluorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: (R)-tert-butyl 3-((R)-(3-fluorophenyl)(hydroxy)methyl)piperidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

ethyl bromoacetate; In tetrahydrofuran; for 3 - 5h; Heating / reflux;