{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

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Chemical Name:{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester
CAS No.:190904-23-5
Molecular Formula:C₂₈H₄₈N₂O₇
Molecular Weight:524.698
Hs Code.:

Synonyms:{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

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Chemical Property of {tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

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Technology Process of {tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

There total 6 articles about {tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: Cyclopentylamino-acetic acid methyl ester; hydrochloride

: 190904-21-3
(2R)-2-[(tert-butoxycarbonyl)(2-tert-butoxy-2-oxoethyl)amino]-3-cyclohexylpropanoic acid

: 190904-23-5
{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0960-894X(98)00650-7

Reference yield:

: 127095-92-5
N-tert-butoxycarbonyl-D-cyclohexylalanine

: 190904-23-5
{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / TBTU, Et₃N / CH₂Cl₂ / Ambient temperature

2: 100 percent / TFA / CH₂Cl₂ / Ambient temperature

3: 80 percent / DIPEA / acetonitrile / 50 °C

4: 95 percent / NEt₃ / methanol / Ambient temperature

5: 100 percent / aq. NaOH / dioxane / Ambient temperature

6: 61 percent / TBTU, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(98)00650-7

Reference yield:

: 769891-92-1,789460-77-1
(R)-2-Amino-3-cyclohexyl-propionic acid methyl ester

: 190904-23-5
{tert-Butoxycarbonyl-[(R)-2-cyclohexyl-1-(cyclopentyl-methoxycarbonylmethyl-carbamoyl)-ethyl]-amino}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / DIPEA / acetonitrile / 50 °C

2: 95 percent / NEt₃ / methanol / Ambient temperature

3: 100 percent / aq. NaOH / dioxane / Ambient temperature

4: 61 percent / TBTU, Et₃N / dimethylformamide / Ambient temperature

With sodium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(98)00650-7