1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol

Base Information

• Chemical Name: 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol
• CAS No.: 1458654-36-8
• Molecular Formula: C₁₄H₁₉BrO₄S
• Molecular Weight: 363.272
• Mol file: 1458654-36-8.mol

Synonyms:1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol

Chemical Property of 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol

There total 5 articles about 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol (1373115-06-0) → 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol (1458654-36-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 - 20 ℃; for 12h;

Reference yield:

4-bromo-3,5-dimethylphenol (7463-51-6) → 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol (1458654-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / -10 - 20 °C

With caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) → 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol (1458654-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 1 h

1.2: 12 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / -10 - 20 °C

With sodium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

4-bromo-3,5-dimethylphenol

Tetrahydrothiopyran-4-one

1-oxa-6-thiaspiro<2.5>octane

4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol

Downstream raw materials:

methyl 2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid