4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol

Base Information

• Chemical Name: 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol
• CAS No.: 1373115-06-0
• Molecular Formula: C₁₄H₁₉BrO₂S
• Molecular Weight: 331.274
• Mol file: 1373115-06-0.mol

Synonyms:4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol

Chemical Property of 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol

There total 2 articles about 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-oxa-6-thiaspiro<2.5>octane (185-73-9) + 4-bromo-3,5-dimethylphenol (7463-51-6) → 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol (1373115-06-0)

Guidance literature:

4-bromo-3,5-dimethylphenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

1-oxa-6-thiaspiro<2.5>octane; In N,N-dimethyl-formamide; mineral oil; at 0 - 80 ℃;

DOI:10.1021/jm2016123

Reference yield:

Tetrahydrothiopyran-4-one (1072-72-6) → 4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol (1373115-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; dimethyl sulfoxide / 1 h

1.2: 12 h

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C

With sodium hydride; caesium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-[(4-bromo-3,5-dimethylphenoxy)methyl]tetrahydro-2H-thiopyran-4-ol (1373115-06-0) → 1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol (1458654-36-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 - 20 ℃; for 12h;

upstream raw materials:

1-oxa-6-thiaspiro<2.5>octane

4-bromo-3,5-dimethylphenol

Tetrahydrothiopyran-4-one

Downstream raw materials:

2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

methyl 2-((S)-6-((R)-7-fluoro-4-(4-((1,1-dioxo-4-hydroxytetrahydro-2H-thiopyran-4-yl)methoxy)-2,6-dimethylphenyl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate

1,1-dioxo-4-((4-bromo-3,5-dimethylphenoxy)methyl)tetrahydro-2H-thiopyran-4-ol