5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol

Base Information

• Chemical Name: 5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol
• CAS No.: 51420-73-6
• Molecular Formula: C10H4F6N2O
• Molecular Weight: 282.14
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID90420778
• Mol file: 51420-73-6.mol

Synonyms:51420-73-6;5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol;5,7-bis(trifluoromethyl)-1,8-naphthyridin-2-ol;5,7-bis(trifluoromethyl)-1H-1,8-naphthyridin-2-one;Bionet2_000140;5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2(1H)-one;SCHEMBL11721081;DTXSID90420778;NLJMPLJFQHFXMB-UHFFFAOYSA-N;HMS1364G08;MFCD00140206;AKOS005071274;CS-0327104;FT-0639994;9D-046;A828577;J-516552

Chemical Property of 5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol

Chemical Property:

• Vapor Pressure: 0.000571mmHg at 25°C
• Melting Point: 185
• Refractive Index: 1.455
• Boiling Point: 311.2°C at 760 mmHg
• Flash Point: 142°C
• PSA: 46.01000
• Density: 1.547g/cm³
• LogP: 3.37300
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 282.02278173
• Heavy Atom Count: 19
• Complexity: 402

Purity/Quality:

98%Min ^*data from raw suppliers

5,7-bis(trifluoromethyl)[1,8]naphthyridin-2-ol 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=O)NC2=C1C(=CC(=N2)C(F)(F)F)C(F)(F)F

Technology Process of 5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol

There total 4 articles about 5,7-Bis(trifluoromethyl)[1,8]naphthyridin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

7-amino-2,4-bis(trifluoromethyl)-1,8-naphthyridine (51420-72-5) → 2-hydroxy-5,7-bis(trifluoromethyl)-1,8-naphthyridine (51420-73-6)

Guidance literature:

With sulfuric acid; sodium nitrite; In acetic acid; for 24h; Reflux;

DOI:10.1021/ol302963e

Reference yield:

2.6-diaminopyridine (141-86-6) → 2-hydroxy-5,7-bis(trifluoromethyl)-1,8-naphthyridine (51420-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 85percent phosphoric acid / 12 h / 60 °C / sealed tube

2: 1) conc.H₂SO₄, sodium nitrite; 2) water / 1) RT, 12 h; 2) boiling steam bath, 30 min

With phosphoric acid; sulfuric acid; water; sodium nitrite;

DOI:10.1002/jhet.5570230238

Reference yield:

1,1,1,5,5,5-hexafluoroacetylacetone (1522-22-1) → 2-hydroxy-5,7-bis(trifluoromethyl)-1,8-naphthyridine (51420-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 85percent phosphoric acid / 12 h / 60 °C / sealed tube

2: 1) conc.H₂SO₄, sodium nitrite; 2) water / 1) RT, 12 h; 2) boiling steam bath, 30 min

With phosphoric acid; sulfuric acid; water; sodium nitrite;

DOI:10.1002/jhet.5570230238

upstream raw materials:

7-amino-2,4-bis(trifluoromethyl)-1,8-naphthyridine

2.6-diaminopyridine

1,1,1,5,5,5-hexafluoroacetylacetone

Downstream raw materials:

7-chloro-2,4-di(trifluoromethyl)-1,8-naphthyridine

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