N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

Base Information

Chemical Name:N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester
CAS No.:1158717-20-4
Molecular Formula:C₂₉H₃₅N₃O₇
Molecular Weight:537.613
Hs Code.:

Synonyms:N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

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Chemical Property of N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

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Technology Process of N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

There total 4 articles about N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1186060-38-7
Boc-L-Glu(OBn)-SH

: 7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8
(S)-tryptophan methyl ester hydrochloride

: 1158717-20-4
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

Guidance literature:: With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/ja2065158

Reference yield: 74.0%

: 1158717-20-4
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

Guidance literature:: With piperidine; In N,N-dimethyl-formamide;

With hydrogenchloride;

With N,O-bis-(trimethylsilyl)-acetamide; In tetrahydrofuran; at 20 ℃; for 8h;

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 1158717-20-4
N-α-tert-butoxycarbonyl-γ-benzyl ester L-glutamyl-L-tryptophan methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: piperidine / N,N-dimethyl-formamide / 1 h / 20 °C

3: N,O-bis-(trimethylsilyl)-acetamide; triethylamine / tetrahydrofuran / 8 h / 20 °C

With piperidine; dmap; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja2065158