tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane

Base Information

• Chemical Name: tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane
• CAS No.: 1296719-10-2
• Molecular Formula: C₁₇H₂₉NO₅Si
• Molecular Weight: 355.506
• Mol file: 1296719-10-2.mol

Synonyms:tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane

Chemical Property of tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane

There total 1 articles about tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-(2,5-dimethoxyphenyl)-2-nitropropan-1-ol (14438-64-3) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane (1296719-10-2)

Guidance literature:

With 1H-imidazole; In dichloromethane; for 16h; Reflux;

DOI:10.1002/ejoc.201001691

Reference yield:

tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane (1296719-10-2) → C17H31NO3Si (1296719-38-4)

Guidance literature:

With ammonia; hydrogen; In methanol; at 50 ℃; for 3h; under 760.051 Torr;

DOI:10.1002/ejoc.201001691

Reference yield:

tert-butyl[1-(2,5-dimethoxyphenyl)-2-nitropropoxy]dimethylsilane (1296719-10-2) → N-[1-(tert-butyldimethylsilyloxy)-1-(2,5-dimethoxyphenyl)propan-2-yl]acetamide (1296719-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia; hydrogen / methanol / 3 h / 50 °C / 760.05 Torr

2: pyridine / dichloromethane / 3 h / 20 °C

With pyridine; ammonia; hydrogen; In methanol; dichloromethane;

DOI:10.1002/ejoc.201001691

upstream raw materials:

1-(2,5-dimethoxyphenyl)-2-nitropropan-1-ol

tert-butyldimethylsilyl chloride

Downstream raw materials:

N-[1-(tert-butyldimethylsilyloxy)-1-(2,5-dimethoxyphenyl)propan-2-yl]acetamide

C₁₇H₃₁NO₃Si