5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

Base Information

Chemical Name:5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol
CAS No.:418776-10-0
Molecular Formula:C₂₀H₂₃N₅OS
Molecular Weight:381.502
Hs Code.:

Synonyms:5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

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Chemical Property of 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

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Technology Process of 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

There total 5 articles about 5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1456620-73-7
N-phenyl-2-{[4-(2-methoxyphenyl)piperazin-1yl]acetyl}hydrazincarbothioamide

: 418776-10-0
5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: With sodium hydroxide; In ethanol; for 0.0833333h; Solvent; Time; Microwave irradiation;
DOI:10.1016/j.cclet.2016.12.012

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 418776-10-0
5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2: hydrazine hydrate / ethanol / 9 h / Reflux

3: ethanol / 6 h / Reflux

4: sodium hydroxide / water / 1 h / Reflux

With hydrazine hydrate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2013.06.045

Reference yield:

: 204973-87-5
[4-(2-methoxyphenyl)piperazin-1-yl]acetohydrazide

: 418776-10-0
5-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-4-phenyl-4H-1,2,4-triazole-3-thiol

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 6 h / Reflux

2: sodium hydroxide / water / 1 h / Reflux

With sodium hydroxide; In ethanol; water;
DOI:10.1016/j.ejmech.2013.06.045