2-CHLORO-5-NITROBENZAMIDE

Base Information

• Chemical Name: 2-CHLORO-5-NITROBENZAMIDE
• CAS No.: 16588-15-1
• Molecular Formula: C7H5ClN2O3
• Molecular Weight: 200.581
• Hs Code.: 29242990
• Mol file: 16588-15-1.mol

Synonyms:2-Chloro-5-nitrobenzamide;NSC 145029;

Chemical Property of 2-CHLORO-5-NITROBENZAMIDE

Chemical Property:

• Vapor Pressure: 0.00122mmHg at 25°C
• Melting Point: 178 °C
• Refractive Index: 1.624
• Boiling Point: 299 °C at 760 mmHg
• PKA: 14.23±0.50(Predicted)
• Flash Point: 134.6 °C
• PSA: 88.91000
• Density: 1.52 g/cm³
• LogP: 2.57060
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-NITROBENZAMIDE

There total 11 articles about 2-CHLORO-5-NITROBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-chloro-5-nitrobenzoic acid (2516-96-3) → 2-chloro-5-nitro-benzamide (16588-15-1)

Guidance literature:

2-chloro-5-nitrobenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;

With ammonium hydroxide; In dichloromethane; Cooling with ice;

Reference yield: 60.0%

4-<(2-Chlor-5-nitrobenzoyl)amino>-3-penten-2-on (104599-67-9) → 2-chloro-5-nitro-benzamide (16588-15-1)

Guidance literature:

With sulfuric acid; for 0.5h; Heating;

Reference yield: 13.0%

4-chloro-3-cyanonitrobenzene (16588-02-6) → 2-chloro-5-nitro-benzamide (16588-15-1)

Guidance literature:

With sodium perborate; In 1,4-dioxane; water; at 89 ℃; for 7h;

upstream raw materials:

4-chloro-3-cyanonitrobenzene

2-chloro-5-nitrobenzoylchloride

4-<(2-Chlor-5-nitrobenzoyl)amino>-3-penten-2-on

nitric acid

Downstream raw materials:

2-chloro-5-nitrobenzoic acid

H₂NC₆H₃(Cl)NO₂

5-nitrosalicylic acid

2-Dibutylamino-5-nitro-benzamide

Refernces

• 1、 -. "AMIDE COMPOUNDS AND MEDICINAL USE THEREOF". Page 51. . Retrieved 2010/01/31.
• 2、 -. "Arylthio compounds". . . Retrieved 2008/06/13.