1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

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Chemical Name:1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid
CAS No.:1187992-02-4
Molecular Formula:C₁₈H₁₇N₅O₄
Molecular Weight:367.364
Hs Code.:

Synonyms:1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

There total 3 articles about 1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 201230-82-2
carbon monoxide

: 1187992-99-9
4-hydroxy-2-(4-iodo-1H-pyrazol-1-yl)-N-(1-methyl-1-phenylethyl)-pyrimidine-5-carboxamide

: 1187992-02-4
1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In dimethyl sulfoxide; at 80 ℃; for 4h;
DOI:10.1021/acs.jmedchem.6b01242

Reference yield:

: 1187990-90-4
4-hydroxy-N-(2-phenylpropan-2-yl)-2-(1H-pyrazol-1-yl)-pyrimidine-5-carboxamide

: 1187992-02-4
1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate; iodine / acetonitrile / 6 h / 85 °C / Inert atmosphere

2: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 4 h / 80 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; ammonium cerium (IV) nitrate; iodine; palladium diacetate; In dimethyl sulfoxide; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01242

Reference yield:

: 585-32-0
2-phenyl-2-propylamine

: 1187992-02-4
1-(4-hydroxy-5-((2-phenylpropan-2-yl)carbamoyl)-pyrimidin-2-yl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole; triethylamine / 1-methyl-pyrrolidin-2-one / 1 h / 70 °C / Inert atmosphere

1.2: 0.5 h / 70 °C / Inert atmosphere

2.1: ammonium cerium (IV) nitrate; iodine / acetonitrile / 6 h / 85 °C / Inert atmosphere

3.1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / dimethyl sulfoxide / 4 h / 80 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; ammonium cerium (IV) nitrate; iodine; palladium diacetate; triethylamine; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01242