Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Base Information

• Chemical Name: Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester
• CAS No.: 154706-33-9
• Molecular Formula: C₃₂H₃₁F₃O₁₀S₃
• Molecular Weight: 728.785

Synonyms:Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Chemical Property of Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

There total 8 articles about Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-anhydro-D-glycero-L-manno-heptononitrile (3737-59-5) → Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester (154706-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ZnCl₂

2: 2.) aq. H₃PO₄ / 1.) THF, 2.) THF

3: 94 percent / pyridine / CH₂Cl₂ / 0 °C

4: DIBAL / tetrahydrofuran / -78 °C

5: DMAP, Et₃N, pyridine

With pyridine; dmap; phosphoric acid; diisobutylaluminium hydride; triethylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00084a005

Reference yield:

[bis(phenylthio)methyl]lithium (13307-76-1) → Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester (154706-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 2.) aq. H₃PO₄ / 1.) THF, 2.) THF

2: 94 percent / pyridine / CH₂Cl₂ / 0 °C

3: DIBAL / tetrahydrofuran / -78 °C

4: DMAP, Et₃N, pyridine

With pyridine; dmap; phosphoric acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00084a005

Reference yield:

benzaldehyde (100-52-7) → Acetic acid (2S,4aR,6R,7S,8S,8aS)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-8-trifluoromethanesulfonyloxy-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester (154706-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ZnCl₂

2: 2.) aq. H₃PO₄ / 1.) THF, 2.) THF

3: 94 percent / pyridine / CH₂Cl₂ / 0 °C

4: DIBAL / tetrahydrofuran / -78 °C

5: DMAP, Et₃N, pyridine

With pyridine; dmap; phosphoric acid; diisobutylaluminium hydride; triethylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00084a005

upstream raw materials:

acetic anhydride

Trifluoro-methanesulfonic acid (2S,4aR,6R,7S,8R,8aS)-7-hydroxy-6-((R)-1-hydroxy-2,2-bis-phenylsulfanyl-ethyl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

2,6-anhydro-D-glycero-L-manno-heptononitrile

[bis(phenylthio)methyl]lithium

Downstream raw materials:

Acetic acid (2S,4aR,6R,7R,8R,8aR)-6-((R)-1-acetoxy-2,2-bis-phenylsulfanyl-ethyl)-8-azido-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

2,2-Dimethyl-propionic acid (2S,4aR,5aR,6R,7R,8aR,9S,9aR)-7-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-phenyl-9-[3-(2,2,2-trichloro-acetyl)-ureido]-octahydro-furo[2',3':5,6]pyrano[3,2-d][1,3]dioxin-6-yl ester

2,2-Dimethyl-propionic acid (2S,4aR,5aR,6R,7R,8aR,9S,9aR)-7-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-9-azido-2-phenyl-octahydro-furo[2',3':5,6]pyrano[3,2-d][1,3]dioxin-6-yl ester

2,2-Dimethyl-propionic acid (2S,4aR,5aR,6R,7R,8aR,9S,9aR)-7-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-9-amino-2-phenyl-octahydro-furo[2',3':5,6]pyrano[3,2-d][1,3]dioxin-6-yl ester

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