Technology Process of (4bS,8aS,9S)-benzyl 3-(benzyloxy)-1-bromo-2-(2-hydroxyethoxy)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
There total 8 articles about (4bS,8aS,9S)-benzyl 3-(benzyloxy)-1-bromo-2-(2-hydroxyethoxy)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium borohydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine; magnesium chloride / propyl cyanide / 192 h / 120 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3: sulfuric acid; dihydrogen peroxide / methanol / 20 °C / Inert atmosphere
4: sodium acetate; bromine / acetic acid / 20 °C / Inert atmosphere
5: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
6: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
With
lithium borohydride; sulfuric acid; dihydrogen peroxide; bromine; sodium acetate; caesium carbonate; triethylamine; magnesium chloride;
In
tetrahydrofuran; methanol; propyl cyanide; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: sodium hydroxide / 1,4-dioxane; water / 20 °C / Inert atmosphere
2: triethylamine; magnesium chloride / propyl cyanide / 192 h / 120 °C / Inert atmosphere
3: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4: sulfuric acid; dihydrogen peroxide / methanol / 20 °C / Inert atmosphere
5: sodium acetate; bromine / acetic acid / 20 °C / Inert atmosphere
6: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
7: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
With
lithium borohydride; sulfuric acid; dihydrogen peroxide; bromine; sodium acetate; caesium carbonate; triethylamine; sodium hydroxide; magnesium chloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; propyl cyanide; water; acetic acid; N,N-dimethyl-formamide;
