(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Base Information

Chemical Name:(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate
CAS No.:1262869-95-3
Molecular Formula:C₂₅H₂₇NO₄
Molecular Weight:405.494
Hs Code.:

Synonyms:(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

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Chemical Property of (4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

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Technology Process of (4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

There total 3 articles about (4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 159723-96-3
N-17-Cbz-3-hydroxymorphinan

: 1262869-95-3
(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: With triethylamine; magnesium chloride; In propyl cyanide; at 120 ℃; for 192h; Inert atmosphere;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262869-95-3
(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2: triethylamine; magnesium chloride / acetonitrile / 120 h / 110 °C / Sealed vessel

With triethylamine; sodium hydroxide; magnesium chloride; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1262869-95-3
(4bS,8aS,9S)-benzyl 2-formyl-3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2: triethylamine; magnesium chloride / acetonitrile / 120 h / 110 °C / Sealed vessel

With triethylamine; sodium hydroxide; magnesium chloride; In 1,4-dioxane; water; acetonitrile;