2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Base Information

• Chemical Name: 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine
• CAS No.: 1145660-05-4
• Molecular Formula: C₁₄H₇ClF₃N₃
• Molecular Weight: 309.678
• Mol file: 1145660-05-4.mol

Synonyms:2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Chemical Property of 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

There total 4 articles about 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine (1145660-04-3) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1145660-05-4)

Guidance literature:

With potassium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 100 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00475

Reference yield: 45.0%

→ 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1145660-05-4)

Guidance literature:

With potassium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield:

6-Chloro-pyridin-3-ylamine (5350-93-6) → 2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1145660-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 96 h / 110 °C / Dean-Stark

2: potassium carbonate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 16 h / 100 °C

With potassium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/acs.jmedchem.7b00475

upstream raw materials:

(E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine

[(p-methylphenyl)sulfonylmethyl]isonitrile

2,4,6-trifluorobenzaldehyde

6-Chloro-pyridin-3-ylamine

Downstream raw materials:

5-[2-bromo-5-(2,4,6-trifluoro-phenyl)-imidazol-1-yl]-2-chloro-pyridine

2-chloro-5-[2,4-dichloro-5-(2,4,6-trifluoro-phenyl)-imidazol-1-yl]-pyridine

2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine