2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Base Information

• Chemical Name: 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine
• CAS No.: 1146767-50-1
• Molecular Formula: C₁₅H₈Cl₂F₃N₃
• Molecular Weight: 358.15
• Mol file: 1146767-50-1.mol

Synonyms:2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Chemical Property of 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

There total 4 articles about 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

2-chloro-5-(4-chloro-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine + methyl iodide (74-88-4) → 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1146767-50-1)

Guidance literature:

2-chloro-5-(4-chloro-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -20 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; at -20 - 20 ℃; for 1h;

DOI:10.1021/acs.jmedchem.7b00475

Reference yield:

2-chloro-5-[2-methyl-5-(2,4,6-trifluoro-phenyl)-imidazol-1-yl]-pyridine (1145660-07-6) → 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1146767-50-1)

Guidance literature:

With N-chloro-succinimide; In chloroform; at 80 ℃; for 3h;

Reference yield:

(E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine (1145660-04-3) → 2-chloro-5-(4-chloro-2-methyl-5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine (1146767-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide; 1,2-dimethoxyethane / 16 h / 100 °C

2.1: N-chloro-succinimide / chloroform / 16 h / 60 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -20 °C

3.2: 1 h / -20 - 20 °C

With N-chloro-succinimide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00475

upstream raw materials:

2-chloro-5-[2-methyl-5-(2,4,6-trifluoro-phenyl)-imidazol-1-yl]-pyridine

(E)-N-(6-chloropyridin-3-yl)-1-(2,4,6-trifluorophenyl)methanimine

methyl iodide

2-chloro-5-(5-(2,4,6-trifluorophenyl)-1H-imidazol-1-yl)pyridine

Downstream raw materials:

5-[4-chloro-5-(2,6-difluoro-4-methoxy-phenyl)-2-methyl-imidazol-1-yl]-2-methoxy-pyridine