(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

Base Information

Chemical Name:(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile
CAS No.:1365998-61-3
Molecular Formula:C₁₇H₂₁FN₄O₃S
Molecular Weight:380.443
Hs Code.:

Synonyms:(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

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Chemical Property of (S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

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Technology Process of (S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

There total 7 articles about (S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 506-68-3
bromocyane

: 1351167-86-6
(S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

: 1365998-61-3
(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

Guidance literature:: bromocyane; (S)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one; With potassium carbonate; In acetonitrile; at 20 ℃;

With sodium hydroxide; In acetonitrile; Product distribution / selectivity;

Reference yield:

: 1351167-88-8
(S)-(4-(1-(benzyloxycarbonyl)piperidin-4-ylamino)-3-(tert-butoxycarbonylamino)-4-oxobutyl)dimethylsulfonium iodide

: 1365998-61-3
(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: sodium carbonate / dimethyl sulfoxide / 48 h / 120 °C

4: hydrogenchloride / palladium 10% on activated carbon / ethanol; water / 18 h / 2068.65 Torr

5: potassium carbonate / acetonitrile / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1351167-90-2
(S)-benzyl 4-(3-amino-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1365998-61-3
(S)-4-(3-(2-fluoro-4-(methylsulfonyl)phenylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / dimethyl sulfoxide / 48 h / 120 °C

2: hydrogenchloride / palladium 10% on activated carbon / ethanol; water / 18 h / 2068.65 Torr

3: potassium carbonate / acetonitrile / 20 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; palladium 10% on activated carbon; In ethanol; water; dimethyl sulfoxide; acetonitrile;