(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate
CAS No.:1351167-87-7
Molecular Formula:C₂₃H₃₅N₃O₅S
Molecular Weight:465.614
Hs Code.:

Synonyms:(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

Suppliers and Price of (S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

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Chemical Property of (S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

There total 1 articles about (S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 120278-07-1
benzyl 4-aminopiperidine-1-carboxylate

: 2488-15-5
N-tert-butoxycarbonyl-L-methionine

: 1351167-87-7
(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

Guidance literature:: N-tert-butoxycarbonyl-L-methionine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

benzyl 4-aminopiperidine-1-carboxylate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 79.0%

: 1351167-87-7
(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

: 74-88-4
methyl iodide

: 1351167-88-8
(S)-(4-(1-(benzyloxycarbonyl)piperidin-4-ylamino)-3-(tert-butoxycarbonylamino)-4-oxobutyl)dimethylsulfonium iodide

Guidance literature:: at 20 ℃; for 4h;

Reference yield:

: 1351167-87-7
(S)-benzyl 4-(2-(tert-butoxycarbonylamino)-4-(methylthio)butanamido)piperidine-1-carboxylate

: 1351168-78-9
(S)-benzyl 4-(3-(6-(methylsulfonyl)pyridin-3-ylamino)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 - 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl acetamide / 100 °C / Inert atmosphere; Sealed tube

With caesium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;