1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Base Information

Chemical Name:1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile
CAS No.:101544-42-7
Molecular Formula:C₂₉H₂₉N₃O₃
Molecular Weight:467.568
Hs Code.:

1-acetyl-5-<1-(acetyloxy)-2-<bis(phenylmethyl)amino>ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Synonyms:1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

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Chemical Property of 1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Chemical Property:

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Technology Process of 1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

There total 8 articles about 1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16078-30-1
1-Acetyl-2,3-dihydro-1H-indole

: 101544-42-7
1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) aluminum chloride / 1.) 1,2-dichloroethane, 20 min, 2.) 1,2-dichloroethane, 50 deg C, 1 h

2: dimethylformamide / 2 h / 60 °C

3: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

4: 94.5 percent / pyridine / Ambient temperature

5: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

6: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

7: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

With pyridine; hydrogenchloride; potassium cyanide; sodium tetrahydroborate; tetrafluoroboric acid; aluminium trichloride; nitric acid; acetic acid; zinc; sodium nitrite; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019

Reference yield:

: 76139-03-2
2-chloro-1-(1-acetyl-2,3-dihydroindole-5-yl)ethanone

: 101544-42-7
1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 2 h / 60 °C

2: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

3: 94.5 percent / pyridine / Ambient temperature

4: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

5: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

6: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

With pyridine; hydrogenchloride; potassium cyanide; sodium tetrahydroborate; tetrafluoroboric acid; nitric acid; acetic acid; zinc; sodium nitrite; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019

Reference yield:

: 101544-39-2
1-acetyl-2,3-dihydro-α-<methyl>-1H-indole-5-methanol

: 101544-42-7
1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 94.5 percent / pyridine / Ambient temperature

2: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

3: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

4: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

With pyridine; hydrogenchloride; potassium cyanide; tetrafluoroboric acid; nitric acid; acetic acid; zinc; sodium nitrite; In ethanol; acetic acid;
DOI:10.1021/jm00156a019