alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride

Base Information

• Chemical Name: alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride
• CAS No.: 110523-42-7
• Molecular Formula: C₄₃H₆₀N₁₂O₁₇*ClH
• Molecular Weight: 1053.48

Synonyms:alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride

Chemical Property of alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride

There total 13 articles about alanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert.-butyloxycarbonylalanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester (110523-41-6) → alanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride (110523-42-7)

Guidance literature:

With hydrogenchloride; In water; acetic acid; for 0.75h; Ambient temperature;

Reference yield:

benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester (110523-36-9) → alanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride (110523-42-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

2: 40 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1) O deg C, 2 h, 2) room temperature, 8 h

3: 96 percent / hydrochloric acid / acetic acid; H₂O / 1 h / Ambient temperature

4: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h

5: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

6: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h

7: 93 percent / hydrogen chloride / acetic acid; H₂O / 0.75 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

asparagine 4-nitrobenzyl ester (37788-09-3) → alanyl-Nε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester hydrochloride (110523-42-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2 h

2: 95 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

3: 40 percent / triethylamine, N,N'-dicyclohexylcarbodiimide / dimethylformamide / 1) O deg C, 2 h, 2) room temperature, 8 h

4: 96 percent / hydrochloric acid / acetic acid; H₂O / 1 h / Ambient temperature

5: 1) N-ethylpiperidine, ethyl chloroformate / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 30 min, then room temperature, 2h

6: 90 percent / hydrogen bromide / acetic acid / 1 h / Ambient temperature

7: 1) triethylamine, 1-hydroxybenztriazole, N,N'-dicyclohexylcarbodiimide / 1) dimethylformamide, -10 deg C, 10 min, 2) 0 deg C, 2 h, room temperature, 8 h

8: 93 percent / hydrogen chloride / acetic acid; H₂O / 0.75 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In water; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

tert.-butyloxycarbonylalanyl-N^ε-benzyloxycarbonyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester

asparagine 4-nitrobenzyl ester

benzyloxycarbonylseryl-asparagine 4-nitrobenzyl ester

seryl-asparagine 4-nitrobenzyl ester hydrobromide

Downstream raw materials:

pyroglutamyl-alanyl-N^ε-benzyloxycarbonyllysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester

pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine

benzyloxycarbonylglutaminyl-alanyl-N^ε-benzyloxycarbonyllysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine 4-nitrobenzyl ester

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