3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol

Base Information

• Chemical Name: 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol
• CAS No.: 536725-05-0
• Molecular Formula: C₂₄H₁₈O₂S
• Molecular Weight: 370.472
• Mol file: 536725-05-0.mol

Synonyms:3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol

Chemical Property of 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol

There total 4 articles about 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

dipropargyl sulfide (13702-09-5) + 1-(4-iodophenyl)-1-propyn-3-ol (116815-00-0) → 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol (536725-05-0)

Guidance literature:

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride;

DOI:10.1016/S0040-4039(03)00148-5

Reference yield:

p-aminoiodobenzene (540-37-4) → 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol (536725-05-0)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl; NaNO₂; K₂CO₃ / H₂O; acetonitrile

2: 100 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂

3: 74.8 percent / iodine; MeI

4: 90.2 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂

With hydrogenchloride; copper(l) iodide; iodine; potassium carbonate; triethylamine; sodium nitrite; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; 2: Sonogashira coupling / 4: Sonogashira coupling;

DOI:10.1016/S0040-4039(03)00148-5

Reference yield:

1-(4-iodophenyl)-3,3-diethyltriazene → 3-[4-(3-{3-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-prop-2-ynylsulfanyl}-prop-1-ynyl)-phenyl]-prop-2-yn-1-ol (536725-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂

2: 74.8 percent / iodine; MeI

3: 90.2 percent / CuI; Et₃N / Pd(PPh₃)2Cl₂

With copper(l) iodide; iodine; triethylamine; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; 1: Sonogashira coupling / 3: Sonogashira coupling;

DOI:10.1016/S0040-4039(03)00148-5

upstream raw materials:

dipropargyl sulfide

1-(4-iodophenyl)-1-propyn-3-ol

p-aminoiodobenzene

Downstream raw materials:

C₂₄H₁₆Br₂S