methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

Base Information

Chemical Name:methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate
CAS No.:1428305-99-0
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

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Chemical Property of methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

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Technology Process of methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

There total 6 articles about methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428305-97-8
C₂₃H₂₇N₅O₅

: 1428305-99-0
methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 6h;
DOI:10.1021/jm301882a

Reference yield:

: 184643-69-4
1-(4-bromo-1-methyl-1H-pyrrol-2-yl)-2,2,2-trichloroethan-1-one

: 1428305-99-0
methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / 0.5 h / Reflux

1.2: pH 2

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

3.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 6 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 6 h / 20 °C

With hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/jm301882a

Reference yield:

: 96-54-8
N-Methylpyrrole

: 1428305-99-0
methyl 4-(4-(4-aminophenyl)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-imidazole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether; tetrahydrofuran / 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 6 h / -10 - 20 °C

3.1: sodium methylate / 0.5 h / Reflux

3.2: pH 2

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 100 °C / Microwave irradiation; Inert atmosphere

5.1: sodium hydroxide / 1,4-dioxane / 6 h / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 6 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane; methanol / 6 h / 20 °C

With hydrogenchloride; dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;
DOI:10.1021/jm301882a