(S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride

Base Information

• Chemical Name: (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride
• CAS No.: 74814-27-0
• Molecular Formula: C₂₂H₂₈N₂O₃*ClH
• Molecular Weight: 404.937
• Mol file: 74814-27-0.mol

Synonyms:(S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride

Chemical Property of (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride

There total 3 articles about (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butoxycarbonyl-α-methyl-L-phenylalanyl-L-valine benzyl ester (74825-82-4) → (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride (74814-27-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 3h;

DOI:10.1021/jm00184a010

Reference yield:

(S)-2-(((1,1-dimethyl)ethoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid (53940-88-8,86778-91-8,111771-58-5) → (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride (74814-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, diethylphosphoryl cyanidate (DEPC) / dimethylformamide / 52 h / 0 - 25 °C

2: 4 N aq. HCl / dioxane / 3 h / 25 °C

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00184a010

Reference yield:

L-valine benzyl ester hydrochloride (2462-34-2) → (S)-2-((S)-2-Amino-2-methyl-3-phenyl-propionylamino)-3-methyl-butyric acid benzyl ester; hydrochloride (74814-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N, diethylphosphoryl cyanidate (DEPC) / dimethylformamide / 52 h / 0 - 25 °C

2: 4 N aq. HCl / dioxane / 3 h / 25 °C

With hydrogenchloride; diethyl cyanophosphonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00184a010

upstream raw materials:

tert-butoxycarbonyl-α-methyl-L-phenylalanyl-L-valine benzyl ester

(S)-2-(((1,1-dimethyl)ethoxycarbonyl)amino)-2-methyl-3-phenylpropanoic acid

L-valine benzyl ester hydrochloride

Downstream raw materials:

Boc-Tyr-D-Ala-Gly-Phe(αMe)-Val-OH