5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

Base Information

Chemical Name:5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine
CAS No.:1383983-00-3
Molecular Formula:C₂₃H₂₄ClN₃O₂
Molecular Weight:409.915
Hs Code.:

Synonyms:5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

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Chemical Property of 5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

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Technology Process of 5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

There total 8 articles about 5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1383982-99-7
5'-bromo-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

: 63503-60-6
3-chlorophenylboronic acid

: 1383983-00-3
5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 120 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1383985-84-9
5'-bromo-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazole]-4(3H)-thione

: 1383983-00-3
5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 120 °C / Microwave irradiation; Sealed vial

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With ammonia; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water;

Reference yield:

: 93777-26-5
5-bromo-2-fluorobenzaldehyde

: 1383983-00-3
5'-(3-chlorophenyl)-4-methoxy-5-methyldispiro[cyclohexane-1,2'-[1]benzofuran-3',2-imidazol]-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap / tetrahydrofuran / 4 h / 20 °C

2.1: lithium hexamethyldisilazane / acetonitrile / 1.5 h / -78 °C

2.2: 3 h / -78 °C

2.3: -78 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 70 °C / Microwave irradiation

4.1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 21 h / Reflux

5.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

6.1: methanol / 24 h / 60 °C / Inert atmosphere

7.1: ammonia / methanol / 120 °C / Microwave irradiation; Sealed vial

8.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 120 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; dmap; titanium(IV) tetraethanolate; potassium tert-butylate; ammonia; potassium carbonate; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;