(4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide

Base Information

• Chemical Name: (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide
• CAS No.: 143837-97-2
• Molecular Formula: C₂₁H₂₅ClN₂O₂
• Molecular Weight: 372.895
• Mol file: 143837-97-2.mol

Synonyms:(4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide

Chemical Property of (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide

There total 3 articles about (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloropropionyl chloride (7623-09-8) + (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-azapentanamide (143746-58-1) → (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide (143837-97-2) + (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2R)-2-chloropropion-1-yl)-3-azapentanamide (143746-59-2)

Guidance literature:

With sodium carbonate; In water; acetone; at 0 ℃; for 1h; Yield given;

DOI:10.1021/jo00050a030

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide (143837-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / ethanol / 8 h / Heating

2: Na₂CO₃*10 H₂O / acetone; H₂O / 1 h / 0 °C

With sodium carbonate; potassium carbonate; In ethanol; water; acetone;

DOI:10.1021/jo00050a030

Reference yield:

2-chloro-N-((1S)-1-phenylethyl)acetamide (36293-01-3) → (4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-((2S)-2-chloropropion-1-yl)-3-azapentanamide (143837-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / K₂CO₃ / ethanol / 8 h / Heating

2: Na₂CO₃*10 H₂O / acetone; H₂O / 1 h / 0 °C

With sodium carbonate; potassium carbonate; In ethanol; water; acetone;

DOI:10.1021/jo00050a030

upstream raw materials:

2-chloropropionyl chloride

(4S)-N-((S)-1-phenyleth-1-yl)-4-phenyl-3-azapentanamide

(S)-1-phenyl-ethylamine

2-chloro-N-((1S)-1-phenylethyl)acetamide

Downstream raw materials:

(3R,6R)-1,4-N,N-((S)-1-phenyleth-1-yl)-3,6-dimethylpiperazine-2,5-dione

(3R,6S)-1,4-N,N-((S)-1-phenyleth-1-yl)-3,6-dimethylpiperazine-2,5-dione

(3R)-<3-methyl-1,4-bis(S)-1-phenylethyl>-piperazine-2,5-dione