N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester

Base Information

• Chemical Name: N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester
• CAS No.: 295800-32-7
• Molecular Formula: C₃₅H₄₁N₃O₇
• Molecular Weight: 615.726
• Mol file: 295800-32-7.mol

Synonyms:N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester

Chemical Property of N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester

There total 5 articles about N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ethyl oxalyl chloride (4755-77-5) + N'-(5-amino-2-methoxy-benzoyl)-hydrazinecarboxylic acid 2,7-di-tert-butyl-9H-fluoren-9-ylmethyl ester (295800-31-6) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester (295800-32-7)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/ja001142w

Reference yield:

2-methoxy-5-nitrobenzoic acid (40751-89-1) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester (295800-32-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 0.5 h

2: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 2 h

3: 99 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; 1: Acylation / 2: Reduction / 3: Acylation;

DOI:10.1021/ja001142w

Reference yield:

N'-(2-methoxy-5-nitro-benzoyl)-hydrazinecarboxylic acid 2,7-di-tert-butyl-9H-fluoren-9-ylmethyl ester (287381-48-0) → N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid ethyl ester (295800-32-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol; tetrahydrofuran / 2 h

2: 99 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

With pyridine; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1021/ja001142w

upstream raw materials:

Ethyl oxalyl chloride

N'-(5-amino-2-methoxy-benzoyl)-hydrazinecarboxylic acid 2,7-di-tert-butyl-9H-fluoren-9-ylmethyl ester

2-methoxy-5-nitrobenzoic acid

2,7-di-tert-butyl-9-fluorenylmethoxycarbonyl chloride

Downstream raw materials:

N-{3-[N'-(2,7-di-tert-butyl-9H-fluoren-9-ylmethoxycarbonyl)-hydrazinocarbonyl]-4-methoxy-phenyl}-oxalamic acid