<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

Base Information

Chemical Name:<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine
CAS No.:236388-00-4
Molecular Formula:C₃₂H₄₅NO₉Si
Molecular Weight:615.796
Hs Code.:

<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

Synonyms:<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

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Chemical Property of <(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

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Technology Process of <(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

There total 18 articles about <(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 236387-99-8
Imidazole-1-carbothioic acid O-[(R)-7-{(S)-[(4S,5S)-5-(benzyloxyimino-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-methoxymethoxy-methyl}-5-(tert-butyl-dimethyl-silanyloxy)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromen-8-yl] ester

: 236388-00-4
<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃;
DOI:10.1021/ja00132a047

Reference yield:

: (4S,5S)-5-{(S)-[(R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromen-7-yl]-methoxymethoxy-methyl}-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde O-benzyl-oxime

: 236388-00-4
<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / 1,2-dichloro-ethane / 14 h / Heating

2: 2,2-azobis<2-methylpropionitrile>, Bu₃SnH / toluene / 0.5 h / Heating

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo9902042

Reference yield:

: 236387-98-7
(7S)-7-((1S)<(5S,4R)-5-<(1Z)-2-aza-2-(phenylmethoxy)vinyl>-2,2-dimethyl(1,3-dioxolan-4-yl)>-3-(methoxymethoxy)-2-(1,1,2,2-tetramethyl-1-silapropoxy))-2H-1,3-dioxoleno<4,5-g>isochroman-8-one

: 236388-00-4
<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

Guidance literature:: Multi-step reaction with 3 steps

1: 205 mg / NaBH₄ / methanol / 2 h / Ambient temperature

2: DMAP / 1,2-dichloro-ethane / 14 h / Heating

3: 2,2-azobis<2-methylpropionitrile>, Bu₃SnH / toluene / 0.5 h / Heating

With dmap; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo9902042